ResearchAug 3, 2026
Correction for You et al., p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
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ResearchAug 3, 2026
Correction for Gardner et al., Competing models of hominin body size evolution
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
ResearchAug 3, 2026
Antibiotic tolerance coupled with limited benefit from drainage: Clinical challenges in Klebsiella pneumoniae liver abscess
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
ResearchAug 3, 2026
The macromolecular native thick filament reveals pathogenic interfaces for hypertrophic cardiomyopathy
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
ResearchAug 3, 2026
One fungus, two trades: Metabolic breadth couples the ability to kill insects to plant symbiosis
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
ResearchAug 3, 2026
How small can a cell be?
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
ResearchAug 3, 2026
Nuclear garbage disposal: An unexpected role for amyloid precursor protein in Alzheimer’s disease
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
ResearchAug 3, 2026
An unseen partner steers alkaloid flux toward vinblastine in Catharanthus roseus
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
ResearchAug 3, 2026
CIP2A–TOPBP1 complex and PP2A dynamically regulate Polθ recruitment and phosphorylation at mitotic DNA double-strand breaks
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceFaithful repair of DNA double-strand breaks (DSBs) during mitosis is critical for genome stability, yet the underlying…
ResearchAug 3, 2026
Bladder mucosal afferents detect UTI and aid pathogen clearance
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceThe bladder is innervated by complex sensory networks, yet the specific role of stretch-insensitive mucosal nerves has…
ResearchAug 3, 2026
Identification of novel functional sites in the Cav1.3 calcium channel α1-subunit using evolutionary modeling
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceVoltage-gated calcium channels regulate critical physiological processes, and some genetic variants inCACNA1Dcan cause…
ResearchAug 3, 2026
Cell surface ADGRG1 and CD86 expression identifies antitumor CD4+ T cells in human cancer
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceStudies have demonstrated that adoptive cell transfer with antitumor CD4+T cells can be effective in treating advanced stage…
ResearchAug 3, 2026
The EV-A71 RNA-binding protein Matrin 3 facilitates viral replication by stabilizing viral RNA via ZDHHC20-mediated palmitoylation
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceSevere hand, foot, and mouth disease caused by Enterovirus 71 (EV-A71) threatens global pediatric health, yet its infection…
ResearchAug 3, 2026
A TCR-mimic bispecific antibody reduces HIV-1 provirus and delays viral rebound in HLA-matched humanized mice
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceAn HIV-1 cure strategy will require novel therapeutics to facilitate immune-mediated elimination of infected cells and…
ResearchAug 3, 2026
SIX1 is required for adult cochlear sensory epithelium homeostasis and auditory function
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceIt remains unclear whether developmental transcription factors sustain adult cochlear function. We show that SIX1, known for…
ResearchAug 3, 2026
The dynamic and heterogeneous structure of the non-canonical inflammasome
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceAnimals respond to injury, infection, or toxic materials via a process called inflammation. At the molecular level…
ResearchAug 3, 2026
Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceOsteoarthritis (OA) is a major cause of pain and disability, yet no approved disease-modifying therapy can halt its…
ResearchAug 3, 2026
Co-phase separation of KRI1 and NPM1 sustains nucleolar integrity and ribosome biogenesis to fuel liver cancer progression
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceThe treatment of hepatocellular carcinoma (HCC) remains challenging, highlighting an urgent need for novel therapeutic…
ResearchAug 3, 2026
Highly flexible vertical electrolyte-gated metal oxide transistors for neuromorphic electronics
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceMetal oxide transistors are important building blocks for large-area, high-resolution displays due to their high carrier…
ResearchAug 3, 2026
Adapting the MasSpec Pen for noninvasive detection of oral cavity squamous cell carcinoma
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceOral cavity squamous cell carcinoma (OCSCC) is a deadly form of head and neck cancer that disproportionately afflicts…
ResearchAug 3, 2026
Optimizing infectious disease mitigation under dynamic conditions
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceManaging a pandemic requires balancing competing costs: interventions such as mask mandates and lockdowns reduce infections…
ResearchAug 3, 2026
Evolution on degenerate fitness landscapes is not random: Curvature drives directional drift
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceEvolutionary dynamics selects more fit phenotypes over others. But fitness landscapes are complex and high dimensional, with…
ResearchAug 3, 2026
Reticulated adaptive radiation and phylogenomic diversity loss in the Hawaiian honeycreepers
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceThe Hawaiian honeycreeper clade is a pre-eminent example of both adaptive radiation and human-mediated rapid extinction. We…
ResearchAug 3, 2026
Deep learning maps local brain aging in relation to cognition across human adulthood
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceAlthough human brain aging is not uniform across cortical regions, most imaging-derived measures of brain age quantify this…
ResearchAug 3, 2026
Controls on glacial erosion rates revealed by cosmogenic nuclide measurements in southeastern Alaska
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceGlacial erosion rates vary over many orders of magnitude, but there are numerous hypotheses predicting the variables that…
ResearchAug 3, 2026
Mapping the exposome–microbiota–host axis for prenatal origins of infant health
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceIn one of the largest prospective pregnancy cohorts with exposome phenotyping, we establish a prenatal…
ResearchAug 3, 2026
Contrastive learning unites sequence and structure in a global representation of protein space
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceHow can the relationships between all known proteins be represented? Recent advances in AI describe proteins as vectors…
ResearchAug 3, 2026
Landscape context constrains climate regulation recovery in Amazonian secondary forests
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceForest regeneration is widely promoted as a strategy to restore ecosystem services in the Amazon, yet whether regenerating…
Clinical PsychologyAug 3, 2026
August 2026 Issues of APA Journals Feature New Research on Schizophrenia, Combined Treatments, Trends in Involuntary Psychiatric Detentions and More
Washington, D.C. — The latest issues of three American Psychiatric Association journals (The American Journal of Psychiatry, Psychiatric Services, and Focus) are now available online. The August issue of The American…
NeuropsychologyAug 3, 2026
Correction: Auditory Processing Disorder in childhood: a critical appraisal of diagnostic validity, functional assessment, and interdisciplinary practice
Behind each article we publish stands a team of superheroes: authors, editors, and reviewers who chose to uphold quality standards and share knowledge openly. Read more about the impact your work achieves. Volume 20…