Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceHerein, we identify α-fluoro-β-alanine (FBAL), a metabolite of 5-fluorouracil (5-FU), as a β-arrestin1-biased ligand of…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceProposed regulatory approaches to promote safe development of AI differentiate between entities developing base models and…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceGlucocorticoids shape postnatal brain development and adaptive plasticity through glucocorticoid receptors (GRs), yet their…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceCatheter-associated urinary tract infections (CAUTIs) are common hospital-acquired infections that can lead to severe…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceGuanidine is widely distributed in nature and has long been considered a toxic metabolic byproduct. Recent studies have…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceThe epidermal growth factor receptor (EGFR) is generally considered to be activated by ligand-induced dimerization…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceRapid diagnostic tests are essential for monitoring health, agriculture, and the environment, yet most lateral flow assays…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceMost birds are specialized for flight. Yet flight is often reduced or lost, and how this occurs is unknown because most losses…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceDuring development, cells collectively change their states to generate tissues and organs. In the 1940s, Conrad Waddington…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceLeishmania, the causative agent of leishmaniasis, has multiple developmental forms as it alternates between a mammalian host…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceMemory representations are influenced by strategies when information is encoded. Scaffolding information within a narrative is…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceOxygen evolution by photosystem II sustains aerobic life and transformed Earth’s early environment by generating the oxygenic…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceMany valuable alkaloids used as pharmaceuticals and chemical intermediates are derived from amino acids but are still mainly…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceFamily research has long emphasized how parents shape their children, but children may also influence their parents. Using…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceMagnetotactic bacteria (MTB) swim along Earth’s magnetic field lines via genetically controlled biomineralization of…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceEnteroviruses are important human pathogens; however, the mechanism by which their genome is released, a prerequisite for…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceManaging the increasing problem of insecticide resistance in malaria vectors requires a detailed understanding of its genetic…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceThe unique geometric understanding of humans has been attributed to an evolutionary divide in symbolic cognition that…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceThe gender pay gap remains a persistent feature of labor markets, yet its sources are difficult to disentangle. Using detailed…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceBats hunt in complete darkness using echolocation, emitting directional high-frequency sonar pulses and analyzing returning…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceOur study demonstrated a causal link between severe floods and opioid overdose mortality in rural Appalachia, a region that…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceEmpirical studies of discrimination typically aim to estimate the effects of race and other legally protected characteristics…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceAI systems are increasingly trained to follow natural language rules, but these rules are often vague or open to multiple…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceWhile SnRK2 kinases, core components of abscisic acid (ABA) signaling, are known to positively regulate drought responses, the…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. Despite substantial excitement around the use of AI in law, little information exists on the performance and associated risks of the…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. Copyright owners have sued several developers of large-scale generative AI systems for copyright infringement because of their uses of…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. Most of our AI governance efforts focus on substance: What rules do we want in place? What limits or checks do we want to impose on AI…
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceIn 2023, the U.S. Supreme Court held inStudents for Fair Admissions v. Harvardthat higher education institutions cannot admit…
The NBER has awarded four Robert Summers fellowships that enable economic statisticians to attend the Conference on Research in ...
Policy analyst Becky Carroll noted that there are a lot of gaps in access to mental health care for children throughout the state, and there could be far-reaching impacts if it is not addressed.