Current reporting, research and professional developments across Neuropsychology, curated for psychologists and behavioral-health professionals.
BackgroundAnti-NMDAR encephalitis is a common form of autoimmune encephalitis with marked clinical heterogeneity. The cerebrospinal fluid (CSF)/serum albumin quotient (QAlb) is a clinically accessible marker reflecting…
IntroductionNeural development is regulated by several spatiotemporally changing factors, which are essential for enabling neurons to develop functional networks, during early developmental stages. Additionally, external…
A multitude of studies have confirmed the essential role of the hippocampus in the acquisition and updating of associative experience. In rodents, spatial memories are dependent on hippocampal information processing and…
Autism spectrum disorder (ASD) shows high variability in brain structure and behavior, complicating identification of biologically meaningful subtypes and their neuroanatomical and molecular bases. To address this, we…
Psychopathy is a personality construct characterized by emotional detachment, impulsivity, and antisocial tendencies. Despite a clinical prevalence of 1%, the biological underpinnings of psychopathy remain poorly…
Orexin receptor 2 (OX2R)-selective agonists have potent wake-promoting effects and could be a promising treatment for sleep/wake disorders, such as narcolepsy type 1. However, OX2R agonists may cause cardiovascular (CV)…
Excitation-Inhibition (E/I) balance is a system-level principle governing healthy neuronal information processing. Its disruption has been implicated in the pathophysiology of multiple sclerosis (MS), yet in vivo…
The insular cortex integrates interoceptive and exteroceptive information to mediate bodily homeostasis, emotion and learning. However, the cellular and circuit substrates governing insular functions are poorly…
Denervated skeletal-muscle atrophy poses a significant challenge in peripheral neurosurgery, with limited recovery of muscle function affecting patients’ quality of life. This study explores the role of the immune…
Fast, highly constrained sensorimotor acts require rapid coordination of distributed cortical systems on subsecond timescales. Here, we used source-resolved magnetoencephalography to characterise time-locked cortical…
Most mammalian offspring are born helpless and depend on sustained parental care for survival, making caregiving one of the most conserved and essential behavioural repertoires in mammals. Yet infant-directed behaviours…
One-shot learningâthe ability to form memories after a single, brief salient eventâis essential for behavioral flexibility in a dynamic world. However, how one-shot learning unfolds in the brain and whether it relies…
Chronically implanted brain-computer interfaces (BCI) for speech have demonstrated restoration of speech communication for people with severe motor impairment. Yet maintaining stable long-term performance remains a…
Parentâoffspring interactions play an important role in offspring survival. Although there is evidence that these interactions are predominantly guided by the right hemisphere, little is still known about the factors…
Improving behavioral performance relies on the ability to associate decisions with their positive and negative outcomes. Although neurons that associate actions with their consequences have been identified across…
Choking under evaluative pressure is often described in sport, yet its within-session neural and behavioural correlates in youth athletes remain poorly characterised. In this exploratory, fixed-order study we asked…
Postsynaptic scaffolding protein SAP90/PSD95-associated protein 3 (SAPAP3) modulates cortico-striatal signalling and regulates the maintenance of synaptic structure. Notably, SAPAP3 defects have been reported in several…
MRI foundation models (FMs) have shown potential for improving performance of neuroimaging tasks, but their value specifically in Glioblastoma overall survival risk prediction remains unclear. In this study, we explored…
Acute noise exposure induces hearing threshold shifts and potentially affects the amygdala, yet the associated metabolic and vascular alterations remain unclear. This study examined the immediate and short-term effects…
Midlife habits . The choices you make during your midlife years can affect your brain health in the future. A recent study published in Neurology Open Access revealed that people ...
Peripheral blood-derived immune cells cross into the aging human brain and transform into functional microglia.
You have an important exam, interview or presentation tomorrow, but sleep simply won't come. Psychology suggests this isn't always a sign of overthinking. Anticipatory anxiety, cognitive arousal, ...
Depression in older adults is tied to volume reduction in the CA23DG hippocampal subfield, independent of Alzheimer's biomarkers.
A new study delivers the first gapless marmoset genome, mapping 76 Alzheimer's-linked genes and novel PSEN1 variants.
A new study introduces the Reproductive Resilience Hypothesis, reframing female reproductive biology as an evolutionary driver of longevity and multi-organ healthspan.
New research indicates dementia risk factors impact the brain uniquely. Common vascular risks damage brain blood vessels and white matter. Diabetes and lower BMI showed links to Alzheimer's proteins.
Hyperphosphorylated tau invades mitochondria and triggers reverse electron transport, opening a novel target for treating Alzheimer's disease and tauopathies.
A new study, published in Neurology Open Access, shows an association between three common vascular risk factors and the amount of dementia-free time people experience after age 55. The study hints that dementia is not…
The extracellular matrix undergoes rapid 24-hour remodeling cycles during learning, locking into place to protect mastered skills.
The brain's immune system has long been thought to exist independently from the rest of the body, complete with its own specialized immune cells and a blood-brain barrier that limits what can travel into the brain.
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